Endocrine Abstracts

Introduction: Metformin is the first-line treatment of type 2 diabetes mellitus. Poor adherence can be lead to poor glycemic control. The aim of our study was to determine the level of metformin adherence and its link with glycemic control in type 2 diabetic patients.Methods: We performed a cross-sectional study including 273 patients with type 2 diabetes taking metformin for at least three years. We assessed metformin adherence using the Girerd question...

Introduction: Insulin allergy is a clinical challenge in the management of type 1 diabetes mellitus since there is no other therapeutic alternative. The specific cause of insulin allergy can be related to insulin itself or to additives including zinc, protamine and meta-cresol. The manifestations range from localized reactions to systemic severe anaphylaxis. We here present the case of a generalized allergy to insulin excipient meta-cresol, in a type 1 diabetic patient success...

Plurihormonal pituitary adenomas represent 10-15% of all functioning pituitary adenomas. Functioning ACTH-GH pituitary adenomas constitute an extremely rare entity. Most patients present a clinically manifested acromegaly and subclinical Cushing’s disease. We present the case of a 14 years old female who referred to the endocrinology department for inaugural diabetic ketosis. She had a six-month history of amenorrhea and headaches. On examination, she had facial dysmporph...

Introduction: Hemochromatosis is associated with iron overload that is responsible of iron deposit causing multiple organ dysfunctions which affects especially endocrine glands.Methods: We report four cases of pituitary hemochromatosis responsible of endocrine dysfunction. Results: Three women and one man were included, aged respectively 28, 19, 26 and 35 years old. These patients were suffering from ß-thalassemia and treated ...

Introduction: Non-functional pituitary adenomas (NFPAs) represent 30% of all pituitary adenomas and not associated with clinical evidence of hormonal hypersecretion. The aim of our study was to describe the clinical and paraclinical aspects of NFPAs.Methods: This is a retrospective descriptive study concerning 40 patients who were hospitalized in the endocrinology department of Rabta hospital in Tunis between January 2014 and December 2020. Clinical and ...

Introduction: Perrault syndrome is a rare autosomal recessive disorder defined by the association of 46XX ovarian dysgenesis and neurosensory deafness. Other manifestations may be present, in particular cerebellar and/or peripheral neuronal degenerative disease. we report the case of Perrault syndrome in a 15-year-old Tunisian girl.Observation: A 15-year-old girl was referred to our department for pubertal delay. She had a congenital deafness and epileps...

Introduction: Gynecomastia is an enlargement of male breast glandular tissue caused by an imbalance of the hormones androgens and estrogens. It can be physiological at different stages of life (birth, adolescence, senescence), caused by medication or reveal a serious pathology. The aim of our study was to evaluate the characteristics of presentation, biochemical profile, and etiology of gynecomastia.Methods: A retrospective study was conducted at the end...

Introduction: Gynecomastia is defined as the benign proliferation of the mammary glands in males, which results from an excess of estrogens, androgen deficiency, hormone resistance, or altered ratio of estrogens to androgens. It can be unilateral or bilateral. The aim of our study was to describe the therapeutic aspects and the evolution of gynecomastia.Methods: This is a retrospective descriptive study of 100 patients who presented with gynecomastia at ...

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women and its main symptoms are related to menstrual disorders and hyperandrogenism. The aim of our study was to evaluate the clinical and paraclinical profile of PCOS.Methods: We conducted a retrospective study that included 50 women, followed at endocrinology department’s consultations of Rabta Hospital in Tunis. Each patient underwent a clinical examin...

Introduction: Hirsutism is often caused by hormonal disorders such as high levels of circulating androgens, hormonal changes related to menopause or disorders of the ovarian or adrenal gland. The aim of our study was to evaluate the clinical and etiological profile of hirsutism.Methods: A retrospective study was conducted at the endocrinology department of Rabta Hospital in Tunis including 100 patients who presented with hirsutism between January 2009 an...